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Title   Cisplatin을 포함한 항암화학용법 치료시 환자에서 발생하는 오심 및 구토에서의 정맥 주사용 및 경구용 Tropisetron과 Ondansetron의 비교 ( Comparison of Tropisetron with Ondansetron in the Preventon of Cisplatin-induced Nausea and Vomiting )
Publicationinfo   1997 Jan; 029(02): 332-340.
Key_word   Nausea, Vomiting, Cisplatin, Tropisetron, Ondnasetron
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Abstract   Purpose: Tropisetron(Nabovan) is a new specific 5-HT receptor antagonist with a long terminal half life in plasma and high bioavailability after oral intake. We compared the antiemetic effectiveness and tolerability of tropisetron with ondansetron in the highly 2 emetogenic chemotherapy(including cisplatin >_ 50 mg/m2). Materials and Methods: Thirty-nine patients were administered in a randomized, multicenter, open, cross-over study and received either tropisetron plus dexamethasone(n=31) or ondansetron plus dexamethasone(n=34) during six days of two successive cycles of chemotherapy. Results: Total control of vomiting with either Ondansetron or tropisetron was 94.2 % vs 93.5 % in Dl(P=0.157); 90.6 % vs 93.1 % in D2(P=0.18); 90.3 % vs 93.1 % in D3(P=0.655); 96.4% vs 96.4 % in D4(P=0.157); 96.4 % vs 100 % in D5(P=0.317); 96.4 % vs 100% in D6, respectively. The duration of nausea showed significant decreasements in tropisetron at D5 and D6 (P=0.025, P=0.03, respectively), but the severity of nausea and performance status showed no significance. Headache and constipation were the most common side effects in both groups. Conclusion: There was no significant difference in efficacy and tolerability between tropisetron and ondansetron in the cisplatin-based chemotherapy.
저 자   이경식(Kyung Sik Lee),한지연(Ji Yeon Han),문한림(Han Rim Moon),이복근(Bok Geun Lee),조석구(Seok Koo Cho),진종률(Jong Ryool Jin),홍영선(Young Sun Hong),김훈교(Hoon Kyo Kim)